nlmixr: Nonlinear Mixed Effects Models in Population Pharmacokinetics and Pharmacodynamics

Fit and compare nonlinear mixed-effects models in differential equations with flexible dosing information commonly seen in pharmacokinetics and pharmacodynamics (Almquist, Leander, and Jirstrand 2015 <doi:10.1007/s10928-015-9409-1>). Differential equation solving is by compiled C code provided in the 'RxODE' package (Wang, Hallow, and James 2015 <doi:10.1002/psp4.12052>).

Version: 1.1.1-1
Depends: R (≥ 3.5)
Imports: Rcpp (≥ 0.12.3), brew, lattice, parallel, lbfgs, dparser, methods, ggplot2, memoise, rex, minqa, Matrix, R.utils, n1qn1, fastGHQuad, crayon, cli, RcppArmadillo (≥ 0.5.600.2.0), vpc (≥ 1.0.0), RxODE (≥ 0.9.1-0), nlme, magrittr, tidyr, sys, generics, huxtable, digest, flextable, stringr, yaml
LinkingTo: dparser (≥ 0.1.8), RxODE (≥ 0.9.1-3), RcppEigen (≥ 0.3.3.3.0), lbfgsb3c, Rcpp, BH, StanHeaders (≥ 2.18.0)
Suggests: knitr, rmarkdown, dplyr, data.table, lbfgsb3c, testthat, madness, devtools, expm, matrixcalc, reshape2, nloptr, ucminf, Rvmmin, broom.mixed, dotwhisker, officer, pkgdown, gridExtra, xpose, drake (≥ 7.5.2)
Published: 2019-08-23
Author: Matthew Fidler ORCID iD [aut], Yuan Xiong [aut], Rik Schoemaker ORCID iD [aut], Justin Wilkins ORCID iD [aut], Mirjam Trame [aut], Richard Hooijmaijers [aut], Teun Post [aut], Robert Leary [ctb], Wenping Wang [aut, cre], Hadley Wickham [ctb], Dirk Eddelbuettel [cph], Johannes Pfeifer [ctb], Robert B. Schnabel [ctb], Elizabeth Eskow [ctb], Emmanuelle Comets [ctb], Audrey Lavenu [ctb], Marc Lavielle [ctb], David Ardia [cph], Bill Denney ORCID iD [ctb], Katharine Mullen [cph]
Maintainer: Wenping Wang <wwang8198 at gmail.com>
License: GPL-2 | GPL-3 [expanded from: GPL (≥ 2)]
URL: https://github.com/nlmixrdevelopment/nlmixr
NeedsCompilation: yes
CRAN checks: nlmixr results

Downloads:

Reference manual: nlmixr.pdf
Vignettes: Running PK models with nlmixr
Package source: nlmixr_1.1.1-1.tar.gz
Windows binaries: r-devel: not available, r-release: not available, r-oldrel: not available
OS X binaries: r-release: not available, r-oldrel: not available
Old sources: nlmixr archive

Linking:

Please use the canonical form https://CRAN.R-project.org/package=nlmixr to link to this page.