mmrm: Mixed Models for Repeated Measures

Mixed models for repeated measures (MMRM) are a popular choice for analyzing longitudinal continuous outcomes in randomized clinical trials and beyond; see Cnaan, Laird and Slasor (1997) <doi:10.1002/(SICI)1097-0258(19971030)16:20%3C2349::AID-SIM667%3E3.0.CO;2-E> for a tutorial and Mallinckrodt, Lane and Schnell (2008) <doi:10.1177/009286150804200402> for a review. This package implements MMRM based on the marginal linear model without random effects using Template Model Builder ('TMB') which enables fast and robust model fitting. Users can specify a variety of covariance matrices, weight observations, fit models with restricted or standard maximum likelihood inference, perform hypothesis testing with Satterthwaite adjusted degrees of freedom, and extract least square means estimates by using 'emmeans'.

Version: 0.1.5
Depends: R (≥ 4.0)
Imports: checkmate (≥ 2.0), lifecycle, methods, nlme, numDeriv, parallel, Rdpack, stats, stringr, TMB (≥ 1.9.1)
LinkingTo: RcppEigen, testthat, TMB
Suggests: emmeans (≥ 1.6), estimability, knitr, rmarkdown, testthat (≥ 3.0.0), xml2
Published: 2022-10-18
Author: Daniel Sabanes Bove [aut, cre], Julia Dedic [aut], Doug Kelkhoff [aut], Kevin Kunzmann [aut], Brian Matthew Lang [aut], Liming Li [aut], Ya Wang [aut], Craig Gower-Page [ctb], Boehringer Ingelheim Ltd. [cph, fnd], Gilead Sciences, Inc. [cph, fnd], F. Hoffmann-La Roche AG [cph, fnd], Merck Sharp & Dohme, Inc. [cph, fnd]
Maintainer: Daniel Sabanes Bove <daniel.sabanes_bove at roche.com>
BugReports: https://github.com/openpharma/mmrm/issues
License: Apache License 2.0
URL: https://openpharma.github.io/mmrm/
NeedsCompilation: yes
Language: en-US
Materials: NEWS
In views: MixedModels
CRAN checks: mmrm results

Documentation:

Reference manual: mmrm.pdf
Vignettes: Details of the Model Fitting in 'mmrm'
Covariance Structures in 'mmrm'
Introduction to 'mmrm'
Package Structure

Downloads:

Package source: mmrm_0.1.5.tar.gz
Windows binaries: r-devel: mmrm_0.1.5.zip, r-release: mmrm_0.1.5.zip, r-oldrel: mmrm_0.1.5.zip
macOS binaries: r-release (arm64): mmrm_0.1.5.tgz, r-oldrel (arm64): mmrm_0.1.5.tgz, r-release (x86_64): mmrm_0.1.5.tgz, r-oldrel (x86_64): mmrm_0.1.5.tgz
Old sources: mmrm archive

Reverse dependencies:

Reverse imports: rbmi

Linking:

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